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Lithium succinate Information
Lithium affects the flow of sodium via nerve and muscle cells in the body. Mania or excitation affects.Lithium is used to treat the manic episodes of manic depression. Manic symptoms include irritability, rushed speech, poor judgment, and decreased need for anger, aggression, and sleep. Lithium helps to stop or lessen the intensity of manic episodes.Lithium may also be used for purposes not listed in this medication guide.
The precise mechanism of action of Li as a mood-stabilizing agent is currently unknown. It’s possible that Li produces its effects by interacting with the transport of monovalent or divalent cations in neurons. An increasing number of scientists have come to the conclusion that the excitatory neurotransmitter glutamate is the vital element in knowing how ion works. Lithium has been shown to modify the inward and outward currents of glutamate receptors (particularly GluR3), with no shift in reversal potential. Lithium was proven to exert a dual effect on glutamate receptors, acting to maintain the amount of glutamate busy between tissues in a secure, healthy degree, neither too much nor too little. It’s postulated that too much glutamate from the distance between neurons triggers mania, and too little, melancholy. Another mechanism by which lithium might help to regulate mood comprise the non-competitive inhibition of an enzyme called inositol monophosphatase. Alternately lithium’s actions might be enhanced via the deactivation of this GSK-3B enzyme. The regulation of GSK-3B by lithium may change the circadian clock. GSK-3 is notorious for phosphorylating and thus inactivating glycogen synthase. GSK-3B has also been implicated in the control of cellular response to damaged DNA. GSK-3 normally phosphorylates beta catenin, which leads to beta catenin degratation. When GSK-3 is inhibited, beta catenin raises and transgenic mice with overexpression of beta catenin express similar behavior to mice treated with lithium. These results indicate that growth of beta catenin may be a possible pathway to the therapeutic action of lithium.
How to use lithium succinate
Follow all instructions. Your physician may occasionally change your dose to be certain that that you find the best results. Do not use this medication in bigger or smaller quantities or for longer than advised. Don’t crush, chew, or break an extended-release tablet. Swallow it whole. Measure liquid medicine with an syringe supplied, or using a distinctive dose-measuring spoon or medicine cup. If you don’t have a dose-measuring device, ask your pharmacist for one. Taking lithium might make it more easy for you to become dehydrated in the event that you have any vomiting or diarrhea, when you exercise vigorously, or if you’re outdoors in the sun or sweat more than normal.
Dehydration can increase some of the negative effects of lithium. Call your physician if you’ve been sick with vomiting or diarrhea and a fever, or whether you are sweating more than usual. While taking needs, it is simple to become dehydrated. Do not change your dose or medication schedule without your doctor’s advice. Drink more fluids each day to prevent dehydration. It might take around 3 weeks before your symptoms improve. Continue using the medicine as directed and tell your doctor if your symptoms don’t start to improve after 1 week of treatment.
If you require surgery, inform the surgeon beforehand that you are using lithium. While using lithium ion, you may require blood tests. Store at room temperature away from heat and moisture.
- increased urination
- fine hand tremor
Nonsteroidal anti-inflammatory medications, , lead to elevated levels of lithium and decrease the kidney’s ability andside effects from lithium. Blood levels of lithium may have to be quantified for 4 days to 7 days after an NSAID is added or ceased during lithium treatment. Sulindac and aspirin don’t seem to influence lithium concentrations in the blood.
Diuretics should be used cautiously in patients. Diuretics that act at the distal renal tubule, , can increase blood levels of lithium. , are inclined to reduce blood levels of lithium. Diuretics such as bumetanide and furosemide might have no affect on lithium concentrations in blood. ACE inhibitors, , may raise the possibility of developing lithium toxicity by increasing the amount of lithium that is reabsorbed into the body at the kidney’s tubules and reducing the excretion of lithium.
Some patients may experience side effects, such as dizziness, lethargy, and tremor when lithium and carbamazepine are used together. Central nervous system side effects also may occur when lithium is used with antidepressants, . Combining lithium using monoamine oxidase inhibitor class of antidepressants can lead to serious reactions. May raise the quantity of lithium that’s lost to the urine.
This reduces the effects of lithium and causes lower blood levels of lithium. Such medications contain sodium citrate, potassium citrate, sodium bicarbonate, and potassium acetate. Caffeine seems to decrease serum lithium concentrations, and unwanted side effects of lithium have grown in frequency when caffeine is absorbed. The two verapamil and diltiazem are reported to have varying impacts on lithium levels in bloodstream.
In some patients there can be decreased lithium blood glucose and in others lithium toxicity. Methyldopa may increase the odds of lithium toxicity. When lithium is handled with phenothiazines reactions have resulted, . Responses have included encephalopathy, seizures, delirium, high fever or specific reactions which affect motion of muscles, known as symptoms. Lithium can lead to hypothyroidism or goiter. Using lithium with potassium iodide may increase the likelihood of this reaction.
The use of the beta blocker together with lithium may cause a slow heart rate and dizziness. Other beta blockers may interact with lithium and also be connected with a slow heart rate.