Trazodone Hydrochloride 25, 50 & 100 mg

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Brand Names
Desyrel, Oleptro

Trazodone hydrochloride Information

Trazodone is an antidepressant medication. It affects chemicals.Trazodone has been used to deal with major depressive disease.Trazodone may also be used for purposes not listed in this medication guide.

Used for treatment: Alcohol Dependence, Anxiety, Insomnia, Major Depressive Disorder

Trazodone binds at 5-HT2 receptor, it functions as a serotonin agonist in high doses and a serotonin antagonist in low doses. Like fluoxetine, trazodone’s antidepressant activity likely results from congestion of serotonin reuptake by inhibiting serotonin reuptake pump at the presynaptic neuronal membrane. If used for extended time periods, postsynaptic neuronal receptor binding sites may also be impacted. The sedative effect of trazodone is likely the consequence of alpha-adrenergic blocking action and modest histamine blockade at H1 receptor. It weakly blocks presynaptic alpha2-adrenergic receptors and strongly inhibits postsynaptic alpha1 receptors. Trazodone doesn’t impact the reuptake of both norepinephrine or dopamine inside the CNS.

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How to use trazodone hydrochloride

Follow all instructions on your prescription label. Your doctor may sometimes change your dose. Do not take this medication in larger or smaller quantities or for longer than advised. The trazodone tablet needs to be taken following a snack or a meal. Take Oleptro in an empty stomach at bedtime or late in the day. Do not crush, chew, or split an extended-release tablet. If necessary an Oleptro tablet will break in half over the score line. It may take as many as two weeks before your symptoms improve.

Continue using the medicine and tell your health care provider if your symptoms do not improve. Do not stop using trazodone abruptly, or you might have withdrawal symptoms. Ask your doctor the way to safely quit using trazodone. Store at room temperature away from heat, moisture, and lighting.

Side Effects

  • attempts to commit suicide
  • feeling very agitated or restless
  • nausea/vomiting
  • new or worse irritability
  • thoughts about suicide or dying
  • dry mouth
  • panic attacks
  • new or worse anxiety
  • acting on dangerous impulses
  • other unusual changes in behavior or mood
  • drowsiness
  • acting aggressive, being angry, or violent
  • dizziness
  • new or worse depression
  • headache
  • trouble sleeping (insomnia)
  • an extreme increase in activity and talking (mania)

Usual Adult Dose for:

Added Dose information:

Usual Adult Dose for Anxiety

Immediate-release pills:
150 mg orally daily in divided doses; that this could possibly be increased by 50 mg orally daily every 3 to 4 times
Maximum dose: 400 mg orally daily in divided doses (outpatients); 600 mg orally daily in divided doses (inpatients)

Extended-release pills:
150 mg orally once a day; this could possibly be raised by 75 mg orally daily every 3 days (i.e., begin 225 mg orally on Day 4 of treatment)
Maximum dose: 375 mg orally daily

-Patients should be monitored for withdrawal symptoms when discontinuing treatment.
-Following an adequate response was attained, dosage might be gradually decreased depending on therapeutic reaction.
-When nausea develops, a significant section of the daily dose can be administered during pregnancy or a decrease in dose may be necessary.
-Immediate release pills should be taken soon after a meal or light snack.
-Extended release tablets should be taken orally at precisely the exact same time daily, from the late night instead of bedtime, on an empty belly.

Usage: Treatment of major depressive disorder (MDD) in adults

Renal Dose Adjustments

Impairment: Use with caution

Liver Dose Adjustments

Impairment: Use with caution


Suicidality and Antidepressant Drugs:
-Antidepressants increased the risk in comparison to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults at short term research of major depressive disorder (MDD) and other psychiatric disorders.
-Anyone thinking about the use of the medication or any other antidepressant in a child, teenager, or young adult have to balance this risk with the clinical requirement. Research didn’t demonstrate a rise in the possibility of suicidality. There was a decrease in risk with antidepressants compared to placebo in adults.
-melancholy and specific other psychiatric ailments are themselves correlated with increases in the probability of suicide. Patients of all ages that are started on treatment observed closely for clinical worsening, suicidality, or unusual changes in behaviour and ought to be monitored. Families and caregivers should be informed of the requirement for close observation and communication.
-This medication isn’t approved for use in pediatric patients.

Safety and effectiveness haven’t been shown in patients younger than 18 decades.

Consult WARNINGS section for further precautions.


Data not available

Other Remarks

Administration information:
-Tablets can be swallowed whole or administered as a half tablet by breaking the tablet along the score line.
-Tablets shouldn’t be crushed or chewed.
-choosing the medication may improves Tolerability.

-Psychiatric: Patients must be monitored for development and worsening of suicidal ideas.

Patient information:
-Patients must be cautioned because this medication may impair the mental and/or physical skills required for the operation of operating a car or machinery.


All antidepressants which raise concentrations of serotonin in the brain, including trazodone, shouldn’t be obtained with MAO-inhibitors. Medicines from the MAO-inhibitor class include phenelzine, isocarboxazid, tranylcypromine, and procarbazine . Such combinations may lead to confusion, high blood pressure and tremor. The kind of interaction could happen when trazodone is used with selegiline. When a patient is switched from trazodone at least one week ought to be allowed after quitting trazodone prior to the MAO inhibitor is begun.

After stopping an MAO inhibitor, fourteen days should elapse before beginning trazodone. Blood concentrations of phenytoin and digoxin have been reported in men taking due to a drop in the metabolism of these drugs by trazodone. Blood levels of trazodone may reduce by increasing its elimination. Ketoconazole, ritonavir, and indinavir inhibit the breakdown of trazodone resulting in increased blood levels of possible and trazodone side effects.

Bleeding may be caused by drugs that increase serotonin. Therefore, combining trazodone with other drugs that affect bleeding, nonsteroidal anti-inflammatory drugs, warfarin or aspirin might increase the probability of upper gastrointestinal bleeding.

Daisy on trazodone.

Trazodone For Sleep and Insomnia

Developed and found in the 1960’s, trazodone was Accepted by the Food and Drug Administration (FDA) for treatment for depression. However, this medicine can be legally prescribed by health care providers for any condition. It is prescribed for treating insomnia and sleep disorders.

Trazodone Has. Clinical studies reveal that roughly 40.8 percent of individuals taking this medicine experience nausea, which makes it among the most frequent side effects of trazodone. Drowsiness can be beneficial although the majority of people today find this unwanted impact for many others. Trazodone is effective as a sleep-aid for those who have sleep and insomnia disorders because of depression. Alternately trazodone may be utilized in the treatment of sleeplessness caused by antidepressants. It might also be prescribed as a sleeping aid for people.

The Way Trazodone Causes Sleep?

The Mechanism of action of trazodone remains unclear medical experts think that it acts by getting nerve cells by preventing the uptake of dopamine.

Serotonin is a chemical messenger or Neurotransmitter that is responsible for relaying messages. It results in results, considering that trazodone interferes with the activity of the receiving nerve cells. The negative effect of trazodone makes it an perfect sleep medication.

What Studies Say?

Despite The limited research conducted on the effectiveness of trazodone as a sleeping aid in patients many health care providers are convinced that it’s a powerful sleep medication.

Studies conducted on patients With varying levels of sleeplessness imply that trazodone raises slow-wave (phase 3 and 4) sleep, or frequently known as heavy sleep. The American Academy of Sleep Medicine recommends trazodone for insomnia when there are sleep medications or no choices have failed.

One Suggests that trazodone isn’t capable of sustaining when used for the management of sleeplessness. The research demonstrated that after the next week, patients weren’t equally responsive to this drug. It follows that increases in dose are essential to attain degree of sedation or the desired result. Trazodone might not be safe to use in patients with sleeplessness.

How to Utilize Trazodone for Sleep Disorders?

When Utilized for sleeplessness or as a sleep-aid, trazodone’s recommended dose is 25 to 50 mg. The dose could be adjusted if required to a maximum dose of 100 mg. Its effect may last up to 8 hours and begins within 1 to 2 hours.

Important notes:

  • Don’t take this medication if you can’t go to bed inside the narrow “window” of sedative effect. Prior to going to bed take trazodone over 60-90 minutes. You might feel tired but have difficulty should you overlook the beginning of effect.
  • Carry trazodone with meals for greater absorption.
  • Trazodone can lead to grogginess or fatigue on the morning after.
  • Don’t try to drive or operate heavy gear upon waking or later taking trazodone, if you don’t have heard its effects on you personally.


Even though Trazodone isn’t suggested for insomnia, it is prescribed as sleep aid. Healthcare providers discover that it’s powerful and it is more affordable. Furthermore trazodone isn’t habit forming or addictive.

But, It’s, because trazodone is connected with potential dangers Recommended that individuals consult with their health care provider before Taking this medication.


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