Alpha-blockers and beta-blockers include substances that simultaneously block both types of adrenergic receptors (carvedilol, labetalol, proxodolol). By blocking both subtypes of beta-adrenergic receptors and alpha1-adrenergic receptors, these agents exhibit typical beta-blocking and peripheral vasodilatory effects. The combination of a decrease in cardiac output and heart rate with vasodilation and a decrease in OPSS causes a rapid antihypertensive effect and a decrease in myocardial contractility, which makes it possible to use them for the treatment of hypertension and in the acute period of dissecting aortic aneurysm. Caution is necessary when using agents of this group in patients with bronchial asthma and with AV blockade, because blockade of beta2-adrenergic receptors of the bronchi can provoke bronchospasm, and beta1-adrenergic receptors of the heart – conduction disturbance.
- Butylaminohydroxypropoxyphenoxymethyl methyloxadiazole (Butylaminohydroxypropoxyphenoxymethyli methyloxadiazolum)
- Carvedilol (Carvedilolum)
Below is a list of alpha and beta blockers: