Drugs capable of shielding postsynaptic alpha-adrenergic receptors from contact with a mediator (norepinephrine) or adrenergic agonists circulating in the blood (endogenous adrenaline, drugs) are divided into selective alpha1-adrenergic blockers (alfuzosin, prazosin, doxulzinosinosin, tamper, and dr. and non-selective, blocking both alpha1- and alpha2-adrenergic receptors (phentolamine, tropodifen, ergot alkaloids and their derivatives, nicergoline, prooxane, butyroxan, etc.). Drugs of this group prevent the passage of vasoconstrictor impulses through adrenergic synapses and thereby cause the expansion of arterioles and precapillaries. Another effect mediated by blockade of alpha1-adrenergic receptors is the improvement of urodynamics in benign prostatic hyperplasia.
Below is a list of alpha blockers:
- Alfuzosin hydrochloride (Alfuzosini hydrochloridum)
- Yohimbine hydrochloride
- Dihydroergotoxin (Dihydroergotoxinum)
- Tamsulosin hydrochloride (Tamsulosini hydrochloridum)