Fibrinolytics, or fibrinolytic agents, cause the destruction of the formed fibrin filaments; they contribute mainly to the resorption of fresh (not yet organized) blood clots.
Fibrinolytic agents are divided into groups of direct and indirect action. The first group includes substances that directly affect blood plasma, a clot of fibrin filaments, effective in vitro and in vivo (fibrinolysin, or plasmin, is an enzyme formed upon activation of profibrinolysin contained in the blood).
The second group includes enzymes – activators of profibrinolysin (alteplase, streptokinase, etc.). They are inactive when directly acting on fibrin strands, but when introduced into the body, they activate the endogenous fibrinolytic system of the blood (convert profibrinolysin into fibrinolysin). The main use as fibrinolytic agents currently have drugs related to indirect fibrinolytics.
Below is a list of fibrinolytics:
- Fibrinolysin (human)
- Recombinant protein containing the amino acid sequence of staphylokinase ()