Drugs belonging to this group interact with n-cholinergic receptors located in the autonomic ganglia (sympathetic and parasympathetic), and the so-called. analogs of ganglionic tissue (carotid sinus and adrenal medulla). In addition, they have the ability to excite n-cholinergic receptors located in the central nervous system.
The main effects of drugs of this group are reflex (through n-cholinergic receptors of the carotid sinus zone) stimulation of the respiratory center (analeptic effect) and an increase in blood pressure as a result of interaction with n-cholinergic receptors of the adrenal chromaffin tissue (increased adrenaline release) and sympathetic ganglia (increased sympathetic impulses to the heart and vessels).
With the advent of drugs with a more selective and pronounced hypertensive action, as well as the expansion of the possibilities of resuscitation measures (mechanical ventilation, etc.), the named effects of n-cholinomimetics have lost their previous clinical significance. Now the main aspect of their use is the reproduction of the n-cholinomimetic effects of nicotine. The use of these drugs can reduce the severity of withdrawal symptoms when smoking cessation.
Below is a list of n-cholinomimetics:
- Nicotine (Nicotinum)
- Cytisin (Cytisinum)