Regenerants and reparants

The normal life of the body is accompanied by a continuous process of replacing dying cells and tissues, called physiological regeneration. Different tissues differ in their ability to restore (regenerate), which is the higher, the greater the role physiological regeneration plays in the structure and functioning of the tissue. The cells of blood, mucous membranes of the gastrointestinal tract, integumentary epithelium of the skin, etc. are rapidly renewed and therefore the tissues that they form are characterized by a high potential for regeneration. On the contrary, in neurons and muscle cells, the regeneration potential is minimal (approaching zero). Under the influence of age, concomitant diseases, toxic and environmental factors, radiation, the process of physiological regeneration can be inhibited. Some drugs have a similar effect, incl. immunosuppressants, antineoplastic drugs, corticosteroids, some antibiotics and NSAIDs, etc. Inhibition of the physiological regeneration process is accompanied by the development of metabolic disorders, the occurrence of leuko- and thrombocytopenia, anemia, damage to the mucous membranes, incl. Gastrointestinal tract, etc. Medicines that can increase the rate and intensity of physiological regeneration are called regeneration stimulants or regenerants.
The restoration of tissue and organ sites that have died as a result of trauma, damage or dystrophy (intoxication, hypoxia, infection, etc.) is a process of reparative regeneration. Accordingly, drugs that have the ability to stimulate regeneration (reparative regeneration) are reparants. As a result of repair, the foci of necrosis are replaced by specific and / or connective tissue (has the highest potential for regeneration) tissue.