Sclerosing

Drugs of this group are used for sclerotherapy for varicose veins, hemorrhoids, telangiectasias, etc. Initially, various chemical compounds were used for this purpose: 5% phenol solution, carbolic acid, metal chlorides and perchlorides. Currently, polidocanol and sodium tetradecyl sulfate are prescribed for sclerotherapy. Both compounds are detergents and have surfactant properties. When administered intravenously, they damage the vascular endothelium and contribute to the formation of a blood clot. Under conditions of compression (bandaging), the walls of the vein collapse, and the fibrous tissue formed as a result of the organization of a thrombus grows together with the walls of the vein. A fibrous scar is formed and partial or complete obliteration of the vein occurs.
Polidocanol, along with the sclerosing effect, has a local anesthetic activity.
Below is a list of sclerosing agents:

  • Sodium tetradecyl sulfate
  • Lauromacrogol 400