Sympatholytics are substances that reduce the amount of a mediator released at the endings of the sympathetic nerves, and thus inhibit the transmission of adrenergic excitation. Unlike adrenergic blockers, sympatholytics do not interact with postsynaptic adrenergic receptors. The main representatives of this group are reserpine, guanethidine, and bretilium tosylate. These drugs are currently not widely used. Reserpine is included in a number of combined antihypertensive drugs.
Below is a list of sympatholytics:

  • Bretylii tosilat
  • Rauwolfia alkaloid
  • Reserpine