Antineoplastic

This pharmacological group includes antineoplastic agents such as protein kinase inhibitors. Below is a list of protein kinase inhibitors: Everolimus Bosutinib Nintedanib (Nintrdanibum) Pazopanib Imatinib Gefitinib Afatinib Ruxolitinib Vemurafenib Ibrutinib (Ibrutinibum) Axitinib Vandetanib Crizotinib Trametinib Sorafenib Dabrafenib Dasatinib Regorafenib Sunitinib Lapatinib Erlotinib Nilotinib Temsirolimus

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The main agents of this group are vinblastine, vincristine, vinorelbine, docetaxel, irinotecan, paclitaxel, teniposide, topotecan, etoposide, etc. According to the classification of D.A. Kharkevich, herbal anticancer agents can be represented by the following groups: 1. Alkaloids of pink vinca – vinblastine, vincristine. 2. Yew tree alkaloids (taxanes) – paclitaxel, docetaxel. 3. Podophyllotoxins secreted from the…

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As antineoplastic agents in clinical practice, a number of hormonal drugs are used – agonists and antagonists of androgens, estrogens, gestagens and other hormones. These funds are indicated mainly for hormone-dependent tumors. Hormonal antitumor therapy is essential in the treatment of breast, endometrial, and prostate cancer. Hormonal agents are also used to treat kidney cancer,…

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Antineoplastic antibiotics – a pharmacological group that combines anticancer antibiotic drugs with antitumor action. The first antitumor antibiotic, dactinomycin, was obtained in 1963. Subsequently, the screening of microbial waste products led to the discovery of a number of effective chemotherapeutic anticancer drugs that are products of different types of soil fungi or their synthetic derivatives.…

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This pharmacological group includes antineoplastic agents such as other antineoplastic agents. Below is a list of other anticancer drugs: Asparaginase (Asparaginasum) Anagrelide Interferon alpha-2b human recombinant (Interferonum alpha-2b) Bortezomib Tretinoin Altretamin Diglycidil methylphosphonate (Diglycidili methylphosphonas) Aflibercept Vorinostat Pomalidomide Miltefosine Mitoxantrone Pegaspargaza Aldesleukin Lenalidomide Tumor necrosis factor-thymosin alpha-1 recombinant () Hydrazine sulfate (Hydrazini sulfas) Hydroxyaluminium trisulfophtalocyanin…

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Antimetabolites are substances that are close in chemical structure to endogenous metabolic products and inhibit, as a result of competitive relations, certain biochemical processes, which is accompanied by a violation of cell function and inhibition of cell growth. The antitumor activity of antimetabolites was discovered in the early 1960s. It turned out that methotrexate, which…

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One of the first to use bis- (beta-chloroethyl) amine derivatives as antitumor agents. The reason for the use of these compounds was the data obtained in the 40s of the XX century. during the Second World War, when the effect on the body of chemical warfare agents was studied in detail: mustard gas (or bis-beta-chloroethyl…

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Antineoplastic drugs (antiblastoma drugs) – drugs that disrupt the development of true tumors (cancer, sarcoma, etc.) and hematological malignancies. According to the international anatomical-therapeutic-chemical classification, they belong to the L code “Antineoplastic and immunomodulating agents”. Cancer treatment is based on the use of three main methods – surgery, radiation therapy and pharmacotherapy, or their various…

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