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Erythromycin sulfate Information
Erythromycin is a macrolide antibiotic. Erythromycin fights bacteria in your system.Protect against or Erythromycin is used to treat unique forms of infections.Erythromycin may also be used for purposes not listed in this medication guide.
Erythromycin acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the “P” or donor website so that binding of tRNA (transfer RNA) into the donor site is blocked. Translocation of peptides in the “A” or acceptor site to the “P” or donor site is averted, and subsequent protein synthesis is inhibited. Erythromycin is effective only against creatures that are actively dividing. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris is not completely known: however, the effect seems to be due in part to the antibacterial activity of the drug.
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How to use erythromycin sulfate
Follow all directions. Your physician may occasionally change your dose to be sure you have the best outcomes. Do not take this medicine in bigger or smaller quantities or for longer than suggested. If a child is using this medication, tell your health care provider if the child has some changes in weight. Erythromycin doses are according to weight in kids.
Do not crush, chew, or break pill or a delayed-release capsule. Measure medicine with all the dosing syringe provided, or with a unique dose-measuring spoon or medicine cup. If you don’t own a dose-measuring device, ask your pharmacist for one. Use this medication. Your symptoms may improve before the infection is completely cleared. Doses may increase. Erythromycin will not treat a viral infection like the frequent cold or flu. This medication can cause results . Tell any doctor who treats you that you are using erythromycin.
Store at room temperature away from moisture, heat, and lighting. You may need to store medication. Carefully follow the storage directions. Liquid medication expires after a very time period. Throw out any remaining liquid as directed.
- Stomach pain
- Common side effects of oral erythromycin include the following:
- Upset stomach
- Skin rash
- Irritation at the site of application, including dryness, redness, itching, and burning
- Stomach cramps
- Mild skin rash
- Irritation at the injection site
Erythromycin when used with antiarrhythmic medications such quinidine, amiodarone, bretylium, disopyramide, dofetilide, procainamide, as and sotalol exaggerates the impact rise to abnormal heart rhythms such as torsades de pointes. By increasing elimination of erythromycin blood levels are reduced by theophyllines like aminophylline, oxtriphylline, and theophylline. Conversely, erythromycin inhibits the metabolism of theophyllines by the liver and also causes an increase.
Theophylline levels that are high may give rise. Therefore, the dose of theophyllines ought to be reduced or levels in the blood ought to be measured in patients. Mixing erythromycin with ergotamine or ydroergotamine has been associated with acute ergot toxicity. This combination ought to be avoided.
Erythromycin prevents digoxin from being eliminated by the kidneys. Increased amounts of digoxin may lead to disturbances . For that reason, it is very important to monitor and adjust digoxin doses when treating with erythromycin. Erythromycin prevents warfarin’s elimination from the body which can raise the levels of warfarin from the blood.
Warfarin is an anticoagulant or blood thinner, and an increase in its level in blood may increase the chance of bleeding. It’s important to monitor the effects of warfarin when treating with erythromycin, and fix warfarin doses. Erythromycin inhibits the breakdown of HMG-CoA reductase inhibitors like lovastatin atorvastatin and simvastatin from the liver leading to increased amounts of statins from the blood.
High levels of statins could lead to acute myopathy with rhabdomyolysis that may damage the kidneys or even cause death. Erythromycin also can raise blood levels of some drugs such as carbamazepine by preventing the breakdown of the anti-seizure medication. Therefore, doses of these drugs may need to be reduced during treatment. Blood levels of sildenafil also increase. The dose of sildenafil ought to be reduced when treating with erythromycin. Grapefruit juice can prevent the breakdown of erythromycin, resulting in elevated levels of erythromycin.
It is important to prevent eating grapefruit or drinking grapefruit juice during treatment with erythromycin.