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Fluvoxamine is a selective serotonin reuptake inhibitor antidepressant. Fluvoxamine affects chemicals in the brain that may be unbalanced in individuals with obsessive-compulsive symptoms. Fluvoxamine is used to treat social anxiety disorder , or obsessive-compulsive ailments involving ideas or actions.Fluvoxamine might also be used for purposes not listed in this medication guide.
The precise mechanism of action of fluvoxamine has not been completely determined, but seems to be linked to its inhibition of CNS neuronal uptake of dopamine. Fluvoxamine blocks the reuptake of dopamine in the serotonin reuptake pump of the adrenal gland, enhancing the actions of serotonin on 5HT1A autoreceptors. In-vitro studies suggest that fluvoxamine is significantly more powerful than clomipramine, fluoxetine, and desipramine as a serotonin-reuptake inhibitor. Studies also have demonstrated that fluvoxamine has almost no affinity for 1- or 2-adrenergic, -adrenergic, muscarinic, dopamine D2, histamine H1, GABA-benzodiazepine, opiate, 5-HT1, or 5-HT2 receptors.
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How to use fluvoxamine
Fluvoxamine is generally taken at nighttime. Follow all instructions on your prescription label. Your doctor may occasionally change your dosage. Do not take this medication in smaller or larger quantities or for longer than advised. You might take fluvoxamine with or without food. Do not crush, chew, break, or open an capsule. You shouldn’t stop using fluvoxamine unexpectedly. About tapering your own dose, follow the instructions of your doctor.
Store at room temperature away from heat and moisture. Keep the bottle tightly closed when not being used.
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All SSRIs, such as fluvoxamine, shouldn’t be taken with some of these monoamine oxidase inhibitor class of antidepressants such as isocarboxazid, phenelzine, tranylcypromine, and procarbazine other medications that inhibit monoamine oxidase such as linezolid and intravenous methylene blue. Such combinations may lead to higher blood pressure, confusion, tremor, and increased activity. Fluvoxamine should not be administered within 14 days of quitting an MAO inhibitor, and MAO inhibitors should not be administered within 14 days of stopping fluvoxamine.
Similar reactions happen if fluvoxamine is blended with other medications, by way of example, tryptophan, St. John’s wort, meperidine, and tramadol that increase serotonin in the brain. Fluvoxamine can inhibit the removal of clozapine. Fluvoxamine increase the blood levels of theophylline, alprazolam, and triazolam resulting in unwanted effects and may inhibit the elimination.
Fluvoxamine may increase the effect of warfarin. Warfarin therapy should be monitored more often in patients who are taking fluoxetine. Combining SSRIs with aspirin, other drugs that affect bleeding or nonsteroidal anti-inflammatory drugs might increase the probability of upper gastrointestinal bleeding.
Fluvoxamine may increase blood levels of tizanidine, thioridazine, alosetron, and pimozide, leading to side effects of the medications.