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Indomethacin is a nonsteroidal anti-inflammatory medication . Indomethacin works by reducing hormones that cause pain and inflammation in the human body.Indomethacin is used in the treatment of moderate to severe osteoarthritis, rheumatoid arthritis, gouty arthritis, or ankylosing spondylitis. Indomethacin is also utilised to treat shoulder pain.Extended-release indomethacin Should not be utilized to treat gouty arthritis.
Indomethacin may also be utilized for purposes not listed in this medication guide.
Indomethacin is a prostaglandin G/H synthase (also known as cyclooxygenase or COX) inhibitor that functions on both prostaglandin G/H synthase 1 and 2 (COX-1 and -2). Prostaglandin G/H synthase catalyzes the conversion of arachidonic acid into a number of prostaglandins involved with fever, pain, swelling, swelling, and platelet aggregation. Indomethacin antagonizes COX by binding into the upper section of the active site, preventing its substrate, arachidonic acid, from entering the active site. Indomethacin, unlike other NSAIDs, also inhibits phospholipase A2, the enzyme responsible for releasing arachidonic acid from phospholipids. Indomethacin is significantly more selective for COX-1 than COX-2, which accounts for its increased adverse gastrointestinal effects relative to other NSAIDs. COX-1 is needed for keeping the protective gastric mucosal layer. The analgesic, antipyretic and anti-inflammatory effects of indomethacin occur as a result of decreased prostaglandin synthesis. Its antipyretic effects might be attributed to action on the hypothalamus, resulting in an increased peripheral blood circulation, vasodilation, and following heat dissipation.
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How to use indomethacin
Follow all instructions. Do not take this medication or for longer than advised. Use. Do not crush, chew, break, or open an capsule. Swallow it whole. Your physician might want to check you on a regular basis to make certain this medicine is not causing harmful effects if you take indomethacin for a time period. Store at room temperature away from moisture and heat. Don’t permit the liquid medicine to freeze.
- renal failure
- ringing in the ears
- coagulation problems
- constant feeling of the need to empty the bowel
- irritation of the rectum
- ringing in the ears
Colestipol and Cholestyramine may decrease the absorption of indomethacin by binding to indomethacin from the intestine and preventing absorption. Indomethacin and other NSAIDs may reduce the elimination of lithium and, thus, increase the blood level. Indomethacin may interfere effects of drugs which are given to reduce blood pressure. This might happen since prostaglandins play a role in the regulation of blood pressure.
The blood levels of aminoglycoside or the methotrexate may increase, presumably because their elimination in the body is reduced when indomethacin is used in combination with methotrexate or aminoglycosides. This may lead to aminoglycoside-related or more methotrexate side effects. Indomethacin ought to be avoided by patients with a history of asthma attacks, hives or other allergic reactions to aspirin or other NSAIDs. If aspirin is taken with indomethacin there may be an increased risk for developing an ulcer.
Individuals that have more than 3 alcoholic drinks per day may be at greater risk of developing stomach ulcers when taking indomethacin or other NSAIDs. Indomethacin increases the impact of cyclosporine and lessens the impact of diuretics because of prostaglandin inhibition. Individuals taking anticoagulants or blood thinners, as an instance should avoid indomethacin since indomethacin also disrupts the blood, and excessive blood thinning can cause bleeding.
PREGNANCY Utilization during pregnancy hasn’t been studied. Indomethacin might have adverse effects on the fetus.