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Nifedipine is actually a group of drugs called calcium channel blockers. This works by relaxing the muscles of the heart and blood vessels.Nifedipine is used to treat hypertension and angina . Nifedipine may also be utilized for purposes.
Nifedipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, an integral step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the primary influx of calcium inhibits the contractile processes of smooth muscle tissues, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. The vasodilatory effects of nifedipine result in a general decline in blood pressure.
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How to use nifedipine
Follow all instructions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than suggested. You may want to have an extended-release pill. Follow the directions on your medicine label about accepting this medication with or without food.
Do not crush, chew, or split an extended-release pillcomputer. Your blood pressure will need to get checked and you may need other blood tests in your doctor’s office. Some types of nifedipine are created with a shell that is not absorbed or melted within the body. Section of the shell may appear in your stool. This won’t make the medicine less effective and is a typical side effect of nifedipine.
Tell the physician ahead of time that you are currently using nifedipine should you require surgery. You might have to quit using the medication at least 36 hours. When taking this medicine, you may have blood pressure. Call your doctor whether you are sweating more than usual, or if you’re ill with diarrhea or vomiting.
If you are carrying a beta-blocker You should not quit using the or you could have. Follow your physician’s directions. You shouldn’t stop using nifedipine. Stopping abruptly may make your condition worse. Continue using this medicine even if you are feeling well if you are being treated for high blood pressure. High blood pressure often has no symptoms. You may want to use blood pressure medication for the rest of your life.
In rare instances, congestive heart failure has been related to nifedipine, usually in patients already on a beta blocker, for example, propranolol , metoprolol, etc.. Excessive lowering of blood pressure during initiation of nifedipine therapy can occur, especially in patients already taking the following blood pressure lowering drug. Normally, nifedipine is prevented in children. The removal of digoxin reduces from the kidneys that could increase digoxin blood circulation and give rise.
It is vital, therefore, to monitor blood levels of digoxin to be able to prevent toxicity. Nifedipine interferes with the breakdown of tacrolimus by the liver, which in turn causes blood levels of tacrolimus and may raise the risk of toxicity from tacrolimus. Nifedipine reduces the blood. Additionally, quinidine increases blood levels of nifedipine and may lead to unwanted effects from nifedipine.
Cimetidine interferes by the liver of nifedipine and increases nifedipine blood flow levels. Cautious dosing is essential when the two medications are administered. Nifedipine should not be taken with grapefruit juice because grapefruit juice inhibits the breakdown of nifedipine by the liver and increases the levels of nifedipine in the blood.