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Ribavirin is an antiviral medication.Ribavirin must be used together with the interferon alfa product To treat chronic hepatitis C. Ribavirin may also be used for purposes not listed in this medication guide.
Ribavirin is reported to have several mechanism of activities that lead to inhibition of viral RNA and protein synthesis.
Ribavirin is phosphorylated intracellularly by adenosine kinase to ribavirin mono-, di-, and triphosphate metabolites. Ribavirin triphosphate (RTP) is the predominant metabolite which immediately inhibits viral mRNA polymerase by binding to the nucleotide binding site of this enzyme. This prevents the binding of the correct nucleotides, leading to a decrease in viral replication or into the creation of defective virions . RTP also shows an inhibitory activity on viral mRNA guanylyltransferase and mRNA 2-O-methyltransferase of dengue virus. Inhibition of the enzymes interrupts the posttranslational capping of the 5 end of viral mRNA via ribavirin being incorporated in the 5 end in place of guanosine and preventing the cap methylation step.
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How to use ribavirin
Follow all directions on your prescription label. Don’t take this medicine in smaller or larger quantities or for longer than advised. When used to deal with hepatitis C Ribavirin isn’t effective. It has to be used together with an interferon alfa product. Take ribavirin with meals. Do not crush, chew, break, or start a ribavirin capsule. Tell your physician if you have trouble.
Measure liquid medication with an syringe supplied, or with a special dose-measuring spoon or medicine cup. If you do not own a dose-measuring device, ask your pharmacist. Utilize ribavirin frequently to get the maximum benefit. Get your prescription refilled before you run out of medicine entirely. Drink extra fluids in hot weather during exercise or while you are taking ribavirin to keep from becoming dehydrated.
Ribavirin may cause dry mouth, which could result in gum infection or tooth decay. If you vomit while taking ribavirin, rinse out your mouth with water to prevent damage. Make sure you have regular examinations as you are taking this medication. Store ribavirin tablets or capsules at room temperature away from moisture, heat, and lighting.
Store ribavirin liquid In the fridge. Do not let it freeze.
- flu-like symptoms – feeling tired, headache, shaking along with high temperature (fever), nausea, and muscle aches.
- Suicidal thoughts and attempts. Adults and children who take ribavirin, especially teenagers, are more likely to have suicidal thoughts or attempt to hurt themselves while taking ribavirin. Call your healthcare provider right away or go to the nearest hospital emergency room if you have new or worse depression or thoughts about suicide or dying.
- Serious breathing problems. Difficulty breathing may be a sign of a serious lung infection (pneumonia) that can lead to death.
- mood changes, feeling irritable.
- stomach pain and vomiting.
- Dental problems. Your mouth may be very dry, which can lead to problems with your teeth and gums.
- a decrease in the blood cells that fight infection (neutropenia).
- Severe depression
- Severe blood disorders. An increased risk when used in combination with pegylated alpha interferons and azathioprine
- Swelling and irritation of your pancreas (pancreatitis). You may have stomach pain, nausea, vomiting, or diarrhea.
- Serious eye problems that may lead to vision loss or blindness.
- Difficulty breathing
- Weight loss and slowed growth in children
- Low blood pressure
- a decrease in appetite.
Ribavirin used at the same time as anti inflammatory drugs with similar mechanisms of action may cause a condition in which lactic acid accumulates. Other such antiviral drugs include those used to manage HIV disease. Adding ribavirin treatment among patients taking azathioprine increases the chance of severe pancytopenia. This happens because ribavirin reduces the breakdown of a compound.