Rosuvastatin

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Brand Names
Crestor

Rosuvastatin Information

Rosuvastatin is in a set of medications called HMG CoA reductase inhibitors, or “statins.” Rosuvastatin reduces levels of “bad” cholesterol And triglycerides in the bloodstream, while increasing levels of “good” cholesterol . Rosuvastatin is used in adults and children That Are at least eight years old, to reduce triglycerides and cholesterol In the blood and to impede the accumulation of plaque in blood vessels.

Rosuvastatin is also used to lower the risk of stroke, heart problems, and other heart problems in certain individuals with coronary heart disease, diabetes, or risk factors.Rosuvastatin is also Utilized to treat forms including the kind And the homozygous kind . For your type that was heterozygous, rosuvastatin can be utilised. For the kind that was homozygous, rosuvastatin may be utilised in children. Rosuvastatin might also be utilized for purposes not listed in this medication guide.

Used for treatment: Atherosclerosis, Atherosclerotic Cardiovascular Diseases, Cardiovascular Diseases, Dysbetalipoproteinemia, Familial hyperlipidemia, Heterozygous Familial Hypercholesterolemia, Homozygous Familial Hypercholesterolemia, Hypertriglyceridemias, Mixed hypercholesterolemia

Rosuvastatin is a competitive inhibitor of HMG-CoA reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA into mevalonate, an ancient rate-limiting step in cholesterol biosynthesis. Rosuvastatin acts primarily in the liver. Decreased hepatic cholesterol levels excite the upregulation of hepatic low density lipoprotein (LDL) receptors that increases hepatic uptake of LDL. Rosuvastatin also inhibits hepatic synthesis of very low density lipoprotein (VLDL). The overall result is a decrease in plasma LDL and VLDL.
In vitro and in vivo animal studies also demonstrate that rosuvastatin exerts vasculoprotective effects independent of its lipid-lowering properties. Rosuvastatin exerts an anti inflammatory effect on rat mesenteric microvascular endothelium by attenuating leukocyte rolling, adherence and transmigration (PMID: 11375257). The medication also modulates nitric oxide synthase (NOS) expression and reduces ischemic-reperfusion accidents in rat hearts (PMID: 15914111). Rosuvastatin increases the bioavailability of nitric oxide (PMID: 11375257, 12031849, 15914111) by upregulating NOS (PMID: 12354446) and by increasing the stability of NOS through post-transcriptional polyadenylation (PMID: 17916773). It’s unclear as to how rosuvastatin brings about such effects though they could possibly be a result of diminished concentrations of mevalonic acid.

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How to use rosuvastatin

Follow all instructions on your prescription label. Your physician may sometimes change your dose. Do not take this medicine in larger or smaller amounts or for longer than suggested. Rosuvastatin is normally taken once each day, with or without food. Take the medication. Blood tests may be needed by you, while using rosuvastatin.

Keep using this medication. High cholesterol generally has no symptoms. You might need to take rosuvastatin on a long-term foundation.

You shouldn’t quit using rosuvastatin unless your physician tells you to. Rosuvastatin is a portion of a treatment program which may include weight control, exercise, and diet. Follow your physician’s instructions very carefully.

Side Effects

  • yellowing of your skin or the whites of your eyes
  • Liver problems. Your health care professional should do blood tests to check your liver before you start taking rosuvastatin and if you have symptoms of liver problems while you take rosuvastatin. Call your doctor right away if you have any of the following symptoms of liver problems:
  • abdominal pain
  • upper belly pain
  • loss of appetite
  • feel unusually tired or weak
  • dark urine
  • nausea
  • headache
  • weakness
  • muscle aches and pains
  • Muscle Problems. Call your health care professional right away if you experience unexplained muscle pain, tenderness, or weakness especially with fever. This may be an early sign of a rare muscle problem that could lead to serious kidney problems. The risk of muscle problems is greater in people who are 65 years of age or older, or who already have thyroid or kidney problems. The chance of muscle problems may be increased if you are taking certain other medicines with rosuvastatin.

Interactions

When administered with cyclosporine, seven fold increases, and the negative effects of rosuvastatin might increase. Rosuvastatin might increase the risk of bleeding from warfarin and raises the blood thinner warfarin’s activity. Antacids reduce the absorption of rosuvastatin and needs to be administered two hours. Using rosuvastatin with nicotinic acid, gemfibrozil or other drugs that may cause liver or muscle injury may increase the prevalence of this muscle injury.

How to pronounce rosuvastatin (Crestor) (Memorizing Pharmacology Flashcard)

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