Terazosin

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Brand Names
Hytrin

Terazosin Information

Terazosin is Actually a group of Medication called alpha-adrenergic blockers. Your arteries and veins relaxe so that blood can pass through them. It calms the muscles in the prostate and bladder neck, making it easier to urinate. Terazosin is used to treat hypertension , or to increase urination in men with benign prostatic hyperplasia .Terazosin may also be used for different purposes.

Used for treatment: Benign Prostatic Hyperplasia, Hypertensive, Ureteral Calculus

In general, О±1-adrenergic receptors mediate contraction and hypertrophic growth of smooth muscle cells. О‘1-Receptors are 7-transmembrane domain receptors coupled to G proteins, including Gq/11. Three О±1-receptor subtypes, which share roughly 75% homology within their transmembrane domains, have already been identified: О±1A (chromosome 8), О±1B (chromosome 5), along with О±1D (chromosome 20). Terazosin is the first О±1-receptor antagonist to demonstrate selectivity for the О±1A-receptor. These two receptor subtypes seem to be involved in maintaining vascular tone. The О±1A-receptor maintains basal vascular tone whereas the О±1B-enzyme mediates the vasocontrictory effects of exogenous О±1-agonists. Activation of О±1-receptors activates Gq-proteins, which results in cerebral stimulation of phospholipases C, A2, and D. This results in mobilization of Ca2 from intracellular stores, activation of mitogen-activated kinase and PI3 kinase pathways and following vasoconstriction. Terozosin creates its pharmacological effects by inhibiting О±1A-receptor activation. Inhibition of these receptors in the vasculature and prostate results in muscle relaxation, decreased blood pressure and improved urinary outflow in symptomatic benign prostatic hyperplasia.

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How to use terazosin

Take exactly as prescribed by your doctor. Do not take in larger or smaller quantities or for longer than advised. Follow the directions. Your doctor may change your dose to make sure to receive the best outcomes. Terazosin reduces blood pressure and may lead to fainting or nausea, especially when you first start taking it, or whenever you start taking it. If it makes you feel light-headed, you might want to choose this medicine at bedtime. Call your doctor if you have severe dizziness or feel as if you could pass out.

When you first wake up, you may feel quite dizzy. Be attentive when standing or sitting up in the lying posture. Should you stop taking terazosin for any reason, call your physician before you begin taking it again. You might need a dose adjustment. Your blood pressure or prostate will have to get checked. Go to your physician regularly. Keep using this medication even if you feel well if you’re being treated for high blood pressure. High blood pressure often has no signs.

You might want to use blood pressure medicine for the rest of your life. Some items may cause your blood pressure to get too low. This includes a low-salt diet, nausea, heavy sweating, heart disease, dialysis, vomiting , or taking diuretics . Tell your health care provider when you have a prolonged illness which leads to nausea or diarrhea. Store at room temperature away from heat, moisture, and lighting.

Side Effects

  • nausea
  • swelling of the feet or hands
  • drowsiness
  • blurred or hazy vision

Interactions

PDE-5 inhibitors used for erectile dysfunction increase the blood pressure and may result in hypotension. Before a PDE-5 inhibitor is started, should be on a stable dose, and the PDE-5 inhibitor ought to be started at the lowest dose. If the individual is already taking a PDE-5 inhibitor terazosin should be started at the lowest dose.

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