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Topiramate potassium Information
Topiramate is a seizure medicine. Topiramate is used to treat seizures in both adults and children that are at least two years old. Trokendi XR is for use in adults and children that are at least 6 years old.Extended-release topiramate has a minimum age When utilized as the child seizure medication. This medicine’s Topamax and Qudexy manufacturers can also be utilised to prevent migraine headaches in adults and teenagers that are 12 or more years old.
Topamax will only stop migraine headaches or reduce the amount of attacks. A headache that’s already begun will not be treated by it.Topiramate may also be utilized for purposes not listed in this medication guide.
The precise mechanism of action of topiramate is not known. However, various studies have proven that topiramate blocks the action potentials elicited repetitively by a sustained depolarization of the neurons at a time-dependent fashion, suggesting that a state-dependent sodium channel blocking activity. Topiramate also strengthens the activity of the neurotransmitter gamma-aminobutyrate (GABA) at some subtypes of the GABAA receptor (controls an integral chloride channel), indicating a possible mechanism via potentiation of the action of GABA. Topiramate also shows antagonism of this AMPA/kainate subtype of the glutamate excitatory amino acid receptor. It also inhibits carbonic anhydrase (especially isozymes II and IV), but this action is weak and not to be related to its anticonvulsant actions.
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How to use topiramate potassium
Follow all directions. Your physician may occasionally change your dosage. Don’t take this medication in larger or smaller amounts or for longer than advised. Topiramate can be obtained with or without food. Don’t crush, chew, or break a tabletcomputer. The Trokendi XR extended-release capsule must be swallowed intact.
Do not open or break. Topamax Sprinkle Capsule and even the Qudexy XR could be swallowed whole. Or you may open the capsule and sprinkle the medicine. Swallow away without chewing. Don’t save the mixture for later use. Adhere to the swallowing instructions for your medication. Blood tests may be needed by you, while utilizing topiramate.
Tell the physician beforehand that you’re currently using topiramate, if you need surgery. Need to know that you take seizure drugs. Drink loads of fluids while you are taking topiramate, to reduce kidney stones or a electrolyte imbalance. Don’t quit using topiramate even in case you’re feeling good. Stopping suddenly may cause seizures that are increased. Follow the instructions of your doctor about tapering your dose. Call your doctor if your seizures get worse or you have them more often while taking topiramate.
Store away from moisture, light, and high heat. Keep the bottle tightly closed when not in use.
- Metabolic acidosis. Metabolic acidosis can cause:
- a change in the way foods taste
- Effects on thinking and alertness. Topiramate may affect how you think and cause confusion, problems with concentration, attention, memory, or speech. Topiramate may cause depression or mood problems, tiredness, and sleepiness.
- Dizziness or loss of muscle coordination.
- upper respiratory tract infection
- Kidney stones. Drink plenty of fluids when taking topiramate to decrease your chances of getting kidney stones.
- High blood ammonia levels. High ammonia in the blood can affect your mental activities, slow your alertness, make you feel tired, or cause vomiting. This has happened when topiramate is taken with a medicine called valproic acid (Depakene and Depakote).
- impaired consciousness
- not feeling hungry
- tingling of the arms and legs (paresthesia)
- irregular heartbeat
- Low body temperature. Taking topiramate when you are also taking valproic acid can cause a drop in body temperature to less than 95В°F, feeling tired, confusion, or coma.
- loss of appetite
- weight loss
These drugs, when taken with topiramate, increase the risk of kidney stones and acidosis: acetazolamide, dorzolamide, methazolamide, dichlorphenamide. Carbamazepine and phenytoin markedly reduce the amount of topiramate from the entire body by increasing its removal. As a result, topiramate may lose effectiveness unless doses are increased. The blood glucose levels may increase and cause hypothermia.
Topiramate may decrease the amount of estrogen within the body in women taking oral contraceptives increasing the chances of breakthrough bleeding and pregnancy. Patients with seizure disorders taking anticonvulsant drugs can develop nerve toxicity from a compound, 4′-O-methylpyridoxine, seen as a contaminant in certain ginkgo preparations.
Metabolic acidosis may be caused by Topiramate. Metformin is contraindicated in patients with metabolic acidosis. Lithium levels may increase at doses that are higher.
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