Topiramate Sodium

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Brand Names
Qudexy XR, Topamax, Topiragen, Trokendi

Topiramate sodium Information

Topiramate is a seizure medicine. Topiramate is used to treat seizures in both children and adults who are at least 2 years old. Trokendi XR is for use in adults and kids who are at least 6 years of age.Extended-release topiramate includes a minimum age When used as the kid’s only seizure medication. Even the Topamax and Qudexy manufacturers of this medication are also utilized to prevent migraine headaches in adults and teens that are at least 12 years old.

Topamax will prevent migraine headaches or reduce the number of attacks. A headache that has already started will not be treated by it.Topiramate may also be utilized for purposes not listed in this medication guide.

Used for treatment: Alcohol Dependence, Binge Eating Disorder, Migraine Headaches, Refractory Status Epilepticus, Spasms, Infantile, Partial onset seizure Epilepsy, Primary generalized tonic-clonic seizure Epilepsy, Weight gain therapy

The precise mechanism of action of topiramate is not known. But, studies have proven that topiramate blocks the action potentials elicited repetitively by a sustained depolarization of the neurons in a time-dependent manner, suggesting a state-dependent sodium channel blocking activity. Topiramate also augments the action of the neurotransmitter gamma-aminobutyrate (GABA) at some subtypes of the GABAA receptor (controls an integral chloride channel), signaling a possible mechanism via potentiation of the action of GABA. Topiramate also shows antagonism of the AMPA/kainate subtype of the glutamate excitatory amino acid receptor. It also inhibits carbonic anhydrase (particularly isozymes II and IV), but this action is weak and not to be related to its anticonvulsant actions.

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How to use topiramate sodium

Follow all directions. Your dose may sometimes change. Do not take this medication in smaller or larger quantities or for longer than advised. Topiramate can be obtained with or without meals. Don’t crush, chew, or break a tablet that is topiramatecomputer. The Trokendi XR capsule has to be swallowed whole. Don’t break or open. Topamax Sprinkle Capsule and the Qudexy XR could be swallowed whole.

Or maybe you open the capsule and sprinkle the medicine to a spoonful of applesauce or other soft food. Swallow away without chewing. Don’t store the mixture for later usage. Follow the instructions on your medication. While using topiramate, you might need blood tests. Should you require surgery, tell the physician beforehand which you are currently using topiramate. Should be aware that you take seizure medication. Drink lots of liquids while you’re taking topiramate, to prevent a electrolyte imbalance or kidney stones.

Don’t stop using topiramate suddenly, even in the event that you’re feeling fine. Stopping suddenly may cause migraines that are increased. Follow the instructions of your doctor about tapering your dose. Call your physician if your seizures get worse or you have them often while taking topiramate. Shop away from high heat, and light, moisture.

Side Effects

  • Metabolic acidosis. Metabolic acidosis can cause:
    • tiredness
    • a change in the way foods taste
    • Effects on thinking and alertness. Topiramate may affect how you think and cause confusion, problems with concentration, attention, memory, or speech. Topiramate may cause depression or mood problems, tiredness, and sleepiness.
    • Dizziness or loss of muscle coordination.
    • diarrhea
    • nausea
    • upper respiratory tract infection
    • Kidney stones. Drink plenty of fluids when taking topiramate to decrease your chances of getting kidney stones.
    • High blood ammonia levels. High ammonia in the blood can affect your mental activities, slow your alertness, make you feel tired, or cause vomiting. This has happened when topiramate is taken with a medicine called valproic acid (Depakene and Depakote).
    • impaired consciousness
    • not feeling hungry
    • tingling of the arms and legs (paresthesia)
    • nervousness
    • irregular heartbeat
    • Low body temperature. Taking topiramate when you are also taking valproic acid can cause a drop in body temperature to less than 95В°F, feeling tired, confusion, or coma.
    • loss of appetite
    • weight loss

    Interactions

    The following drugs, when taken with topiramate, raise the risk of metabolic acidosis dorzolamide dichlorphenamide and kidney stones. Carbamazepine and phenytoin markedly decrease the amount of topiramate in the body by increasing its removal from the body. Unless doses are raised, because of this, topiramate may lose effectiveness. Mixing valproic acid cause hypothermia and may increase the blood glucose levels.

    Topiramate may decrease the amount of estrogen in your system in women taking oral contraceptives increasing the odds of breakthrough bleeding and pregnancy. Patients with seizure disorders taking anticonvulsant drugs may develop nerve toxicity in the chemical, 4′-O-methylpyridoxine. Metabolic acidosis may be caused by Topiramate. Metformin is contraindicated in patients with metabolic acidosis. Lithium levels can increase at doses that are higher.

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