Valsartan

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Brand Names
Diovan

Valsartan Information

Valsartan is an angiotensin II receptor antagonist. Valsartan prevents blood vessels from narrowing, which lowers blood pressure and improves blood flow.Valsartan is used to treat high blood pressure In kids and adults who are at least 6 years old. Valsartan is also used to treat heart failure, and also also to lower the probability of death after a heart attack. Valsartan is given along with other blood pressure medications.Valsartan may also be used for purposes.

Used for treatment: Diabetic Nephropathies, Heart Failure NYHA Class II, Hypertensive, NYHA Class III Heart Failure, NYHA Class IV Heart Failure, Left ventricular dysfuntion

Valsartan is an ARB that selectively inhibits the binding of angiotensin II to AT1, which can be found in many tissues like vascular smooth muscle and the adrenal glands. This effectively inhibits the AT1-mediated vasoconstrictive and aldosterone-secreting effects of angiotensin II and results in a decrease in vascular resistance and blood pressure. Valsartan is selective for AT1 and has virtually no affinity for AT2. Inhibition of aldosterone secretion can inhibit water and sodium reabsorption in the uterus while reducing potassium excretion. The principal metabolite of valsartan, valeryl 4-hydroxy valsartan, has no medicinal action.

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How to use valsartan

Follow all directions on your prescription label. Your doctor may change your dose to make certain that you have the best results. Don’t take this medication in smaller or larger amounts or for longer than recommended. You may take valsartan with or without meals. Take the medication. Your pharmacist and a liquid may combine the medicine if a child taking valsartan can’t swallow a capsule complete. Shake this liquid well just before a dose is measured by you.

You might have very low blood pressure while taking valsartan. Call your doctor whether you are sweating more than normal, or if you are ill with diarrhea or nausea. Your blood pressure will have to get checked often. Your kidney function might have to be assessed. It might take two to four weeks prior to your blood pressure is in check of using this medication.

Continue using this medicine. High blood pressure often has no signs. You might have to use blood pressure medicine for the rest of your life. Speak with your doctor if your symptoms do not improve after 4 months of therapy. Read instruction sheets, drug manuals, and all information supplied to you. Consult your physician or pharmacist if you’ve any queries.

Side Effects

  • joint and back pain
  • flu symptoms
  • tiredness
  • low blood pressure
  • headache
  • dizziness
  • stomach (abdominal) pain
  • dizziness
  • tiredness
  • high blood potassium
  • high blood creatinine (decreased kidney function)
  • cough
  • diarrhea
  • low blood pressure
  • rash

Interactions

Combining valsartan with potassium-sparing diuretics, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to hyperkalemia and in heart failure patients, it raises serum creatinine, a blood test used for monitoring function of the kidneys. Combining valsartan or other ARBs with drugs in patients that are elderly, fluid-depleted, or with poor kidney function may result in decreased kidney function, including kidney failure.

These effects are generally reversible. There are reports that aspirin and other NSAIDs like indomethacin, ibuprofen, and naproxen may lessen the effects of ARBs.